LuckyRx LLC
IMPORTANT SAFETY INFORMATION
Lucky Weekend — Compounded Sublingual Tablet
Active Ingredients: Tadalafil, Vardenafil HCl, Methylcobalamin
⚠ IMPORTANT: NOT FDA-APPROVED
Lucky Weekend is a compounded prescription medication. Compounded medications are permitted to be prescribed under federal law but are NOT FDA-approved and have not undergone the FDA's pre-market review for safety, effectiveness, or quality.
This medication is intended only for the patient to whom it is prescribed. Keep out of reach of children.
This medication is shipped in child-resistant packaging (tin or pharmacy bottle). Store safely where children and others cannot access it, and keep the packaging secured at all times.
This medication does NOT protect against sexually transmitted infections (STIs), including HIV/AIDS. Use appropriate protection.
What is Lucky Weekend?
Lucky Weekend is a compounded sublingual tablet formulated for adult men 18 years of age or older for the treatment of erectile dysfunction. It contains two PDE5 inhibitors (tadalafil and vardenafil HCl) and a nutritional/supportive agent (methylcobalamin, a form of Vitamin B12). It is placed under the tongue and allowed to dissolve for rapid absorption.
Important note regarding combination PDE5 inhibitor formulations: Lucky Weekend contains two PDE5 inhibitors. The additive vasodilatory effects of combining PDE5 inhibitors may increase the risk of hypotension, dizziness, fainting, and cardiovascular events compared to single-agent use. The prescribing physician will independently evaluate whether this combination formulation is medically appropriate based on your individual health history, cardiovascular status, and current medications.
| Ingredient | Role |
|---|---|
| Tadalafil | PDE5 inhibitor — supports erectile function by increasing blood flow; longer duration of action (up to 36 hours); allows for more spontaneous sexual activity |
| Vardenafil HCl | PDE5 inhibitor — enhances erectile response; may work faster than tadalafil in some patients |
| Methylcobalamin | Vitamin B12 derivative — nutritional/supportive agent; generally well-tolerated at standard doses |
How to Take Lucky Weekend
- Place one tablet under your tongue and allow it to dissolve completely. Do not chew, crush, or swallow the tablet whole.
- Take approximately 15 to 30 minutes before planned sexual activity.
- The medication requires sexual arousal to work. It will not cause an automatic erection.
- Effects may last up to 36 hours due to the tadalafil component. Plan accordingly.
- Do not take more than one dose in any 24-hour period.
- Do not take within 24 hours of any other ED medication or any product containing sildenafil, tadalafil, or vardenafil.
- You can take Lucky Weekend with or without food. Do not eat or drink anything while the tablet is dissolving under your tongue.
- Avoid excessive alcohol consumption when using this medication.
- Store at room temperature in a cool, dry place away from light and moisture.
Who Should NOT Take Lucky Weekend
Do not take Lucky Weekend if any of the following apply to you. You must disclose all medications, supplements, and health conditions to your prescribing physician prior to treatment, including any cardiovascular conditions, use of nitrates or alpha-blockers, low blood pressure, recent cardiac events, history of priapism, or any other condition that may affect the safety of these medication classes.
ABSOLUTE CONTRAINDICATIONS — Do not take if:
You are taking nitrates in any form, including nitroglycerin, isosorbide mononitrate, isosorbide dinitrate, or recreational nitrates (poppers/amyl nitrite/butyl nitrite). Combining PDE5 inhibitors with nitrates can cause a dangerous and potentially life-threatening drop in blood pressure.
You are taking guanylate cyclase stimulators such as riociguat (Adempas) or vericiguat (Verquvo) for pulmonary hypertension or heart failure.
You have a known allergy or hypersensitivity to tadalafil, vardenafil HCl, methylcobalamin, or any inactive ingredient in this formulation including cinnamon oil or vanillin.
Your physician has advised you that sexual activity is inadvisable due to cardiovascular risk.
USE WITH CAUTION — Tell your physician if:
- You have cardiovascular disease, heart failure, recent heart attack, stroke, or unstable angina
- You have low blood pressure (hypotension) or are taking antihypertensive medications
- You have a history of priapism (prolonged erection) or conditions predisposing you to priapism
- You have severe kidney or liver impairment
- You have a retinal disorder, including retinitis pigmentosa
- You have a history of hearing or vision loss
- You are taking alpha-blockers for blood pressure or prostate conditions
- You are taking antifungal medications (ketoconazole, itraconazole) or antibiotics (erythromycin, clarithromycin)
- You are taking HIV protease inhibitors
- You are taking any other prescription or over-the-counter medications, supplements, or herbal products
Inactive Ingredients (Excipients): Lucky Weekend contains the following inactive ingredients: Prosolv ODT G2, Mannitol USP, Magnesium Stearate NF, Silicon Dioxide, Bitter-Bloc Pure Powder, MagnaSweet 135 Powder, Cinnamon Oil, Vanillin NF Powder, Triple Mint Natural SD Powder Flavor Concentrate, Emerald Green Natural Food Color Powder. If you have a known sensitivity to any of these ingredients, including cinnamon oil or vanillin, inform your prescribing physician before use.
Drug Interactions
Lucky Weekend has several known drug interactions. This list is not exhaustive. Always inform your prescribing physician and pharmacist of all medications, supplements, and herbal products you are taking.
Medications that require extra caution or may be contraindicated:
- Nitrates (all forms) — absolute contraindication; see above
- Guanylate cyclase stimulators — absolute contraindication; see above
- Alpha-blockers (tamsulosin, doxazosin, terazosin) — may enhance blood pressure lowering effect; start at lowest dose and monitor
- Antihypertensive medications — additive blood pressure lowering effect possible
- CYP3A4 inhibitors (ketoconazole, itraconazole, erythromycin, clarithromycin, ritonavir, saquinavir) — increase tadalafil and vardenafil levels; dose adjustment may be required
- CYP3A4 inducers (rifampin, phenytoin, carbamazepine, phenobarbital) — may decrease effectiveness
- Other PDE5 inhibitors — do not combine
- Alcohol — increases hypotensive effects; avoid excessive consumption
- Grapefruit juice — may increase levels of active ingredients; avoid
- Pre-workout supplements containing beet root extract or organic nitrates — check with pharmacist before use
Side Effects
Common side effects may include:
- Headache
- Flushing (warmth or redness in the face, neck, or chest)
- Nasal congestion
- Indigestion or stomach discomfort
- Back pain or muscle aches — more common with tadalafil; typically resolves within 12 to 48 hours
- Mild vision changes — color-tinged vision, increased light sensitivity, or blurred vision
- Dizziness — particularly when standing quickly
These effects are generally mild and temporary. If they persist or worsen, contact your prescribing physician.
Less common but serious side effects — seek medical attention:
- Sudden decrease or loss of vision in one or both eyes — stop medication and seek immediate medical care
- Sudden decrease or loss of hearing — stop medication and seek immediate medical care
- Fainting or loss of consciousness
- Severe dizziness or lightheadedness
- Chest pain, irregular heartbeat, or shortness of breath during or after sexual activity
⚠ EMERGENCY: Priapism — Prolonged Erection
If you experience an erection lasting longer than 4 hours, seek emergency medical care immediately. Call 911 or go to your nearest emergency room.
Priapism (a prolonged, painful erection) can cause permanent damage to penile tissue if not treated promptly.
Do not wait to see if it resolves on its own. This is a medical emergency.
Prescribing Information
Lucky Weekend is a compounded prescription medication prescribed by independent licensed physicians through LuckyRx's telemedicine platform. It is prepared by a licensed compounding pharmacy and is intended solely for the patient to whom it is prescribed.
This document does not replace the advice or instructions of your prescribing physician or pharmacist. Always read your prescription label and any materials provided by your pharmacy. Contact your physician or pharmacist if you have questions about this medication.
Report Adverse Events
If you experience a serious adverse event, contact LuckyRx support at [email protected] or call 877-403-9319.
You may also report adverse events directly to the FDA at: https://www.accessdata.fda.gov/scripts/medwatch/